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Shanmugam, Kumaran

A Comprehensive Review on Ocimum basilicum

Abstract Views :1139 | PDF Views:302

Authors

Balakrishnan Purushothaman ¹, Ramalingam Prasanna Srinivasan ², Purushothaman Suganthi ², Balu Ranganathan ³, Jolius Gimbun ⁴, Kumaran Shanmugam ¹

Affiliations
1 Department of Biotechnology, Periyar Maniammai Institute of Science & Technology, Thanjavur – 613403, Tamilnadu, IN
2 TANBIO R&D Solution, Periyar Technology Business Incubator, Thanjavur – 613403, Tamilnadu, IN
3 Palms Connect Sdn Bhd, Shah Alam 40460, Selangor Darul Ehsan, MY
4 Centre of Excellence for Advanced Research in Fluid Flow (CARIFF), Universiti Malaysia Pahang, Gambang 26300, Pahang, MY

Source

Journal of Natural Remedies, Vol 18, No 3 (2018), Pagination: 71-85

Abstract

The genus Ocimum has a number of species that are used to treat different types of disorders and diseases from ancient times. In this genus, O. basilicum plays a vital role due to its various medicinal properties. It is universally cultivated as herbaceous, perennial plant but originated from Asian continent. O. basilicum is used as a culinary herb and also has a number of pharmacological activities to prevent or treat cardiovascular disorders, diabetes, menstrual cramps, digestive disorders, neuro-degenerated disorders and cancer. In addition to that, it has been reported for antioxidant, antimicrobial, and larvicidal activities. Chemical constituents such as linalool; eugenol; 1, 8-cineone; methyl eugenol and anthocyanins are mostly responsible for the above mentioned activities. Some traditional uses of this plant coincidences with experimental results. However, the studies conducted based on its traditional use are negligible. This review is an attempt to provide a pharmaceutical perspective of Ocimum basilicum.

Keywords

Cancer, Chemical Constituents, Immunomodulatory, Pharmacological Activity, GC-MS.

Full Text

References

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Qualitative and Quantitative Determination of Various Extracts of Ocimum basilicum L. Leaves

Abstract Views :259 | PDF Views:202

Authors

Balakrishnan Purushothaman ¹, Nagarasan Suganthi ², Kumaran Shanmugam ¹

Affiliations
1 Department of Biotechnology, Periyar Maniammai Institute of Science and Technology, Vallam, Thanjavur – 613 403, Tamil Nadu, IN
2 TanBio R and D Solution, Periyar Technology Business Incubator, Vallam, Thanjavur – 613 403, Tamil Nad, IN

Source

Journal of Natural Remedies, Vol 20, No 1 (2020), Pagination: 53-60

Abstract

Ocimum basilicum L. (Lamiaceae) commonly known as basil possesses various medicinal activities to treat headache, diarrhoea, kidney malfunctions, diabeties, cancer and several pharmacological activities. These are mainly due to the various chemically diversified constituents present in it. In order to evaluate the chemical composition of basil leaves, the dried leaves were extracted with petroleum ether, chloroform, ethyl acetate, methanol and water by Soxhlet’s extraction. The extracts were screened for the qualitative determination by preliminary phytochemical screening. Quantitative determination was also performed for the total alkaloids, flavonoids, phenols, saponins and tannins. Amongst the extracts, methanol (MeOH) was identified to contain various classes of secondary metabolites, so GCMS analysis was performed on the MeOH extract. The results revealed that chemical constituents claimed for various biological activities were present.

Keywords

Chemical Constituents, GCMS, Ocimum basilicum L., Qualitative, Quantitative.

Full Text

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Inhibition of Breast Cancer Proteins by the Flavonoid Naringenin and its Derivative: A Molecular Docking Study

Abstract Views :132 | PDF Views:66

Authors

Shruthi Muralidharan ¹, A. Antony Joseph Velanganni ², Kumaran Shanmugam ¹

Affiliations
1 Department of Biotechnology, Periyar Maniammai Institute of Science & Technology, Thanjavur – 613403, Tamil Nadu, IN
2 Department of Biochemistry, Bharathidasan University, Tiruchirappalli – 620024, Tamil Nadu, IN

Source

Journal of Natural Remedies, Vol 22, No 1 (2022), Pagination: 51 - 64

Abstract

Cancer is a multifaceted disease and is a major health burden in the world. Breast cancer is leading cause of mortality among women worldwide. Plant derived compounds have also been used in the treatment of cancer. Amongst them, flavonoids have been well documented for their therapeutic potential against cancer cells. Naringenin is a flavanone abundantly available in grapefruit and tomato among other sources. Several natural and synthetic derivatives of naringenin have been reported for anticancer activity. In this study, naringenin (Nar) and its derivative, naringenin 2-hydroxy benzoyl hydrazone (Nar-Bhz) were studied for their inhibitory potential against proteins involved in breast cancer. Molecular docking simulation by AutoDock was utilized to investigate the interaction of Nar and Nar-Bhz with Survivin, Estrogen receptor α (ERα), progesterone receptor (PR), Akt1, and Epidermal growth factor receptor (EGFR). Doxorubicin was used as positive control because of its clinical importance in breast cancer treatment. Discovery Studio Visualizer was used to visualize the interactions and the docking results showed that the protein ligand complexes were stabilized by hydrogen bonding and hydrophobic interactions. The binding energies ranged between -7.66 to -7.91 kcal/mol with Nar-Bhz and between -5.49 and -11.05 kcal/mol for Nar. Significant inhibition constant was observed for Nar-Bhz interaction with Akt1 and EGFR. Also, several residues of Akt1 interacted with both the ligands. It can be concluded that naringenin and its derivative have promising inhibitory potential against the breast cancer proteins. The findings of this study may pave the way for detailed exploration of naringenin as breast cancer drug and as a nutraceutical or dietary supplement in daily intake.

Keywords

Breast Cancer, Docking, Flavonoids, Molecular, Naringenin, Naringenin Derivative

Full Text

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Developing Cost-Effective and Efficient Drinking Water Treatment Technology for the Removal of Salinity and Suspended Solids

Abstract Views :150 | PDF Views:76

Authors

P. G. Jansi Rani ¹, C. Vimala ², T. Divya ³, M. B. Anusha ⁴, T. Vinotha ⁵, J. Rajagowri ⁶, Kumaran Shanmugam ⁶

Affiliations
1 Department of Mathematics, Sethu Institute of Technology, Virudhunagar - 626115, Tamil Nadu, IN
2 Department of Mathematics, Periyar Maniammai Institute of Science & Technology (Deemed to be University), Thanjavur - 613403, Tamil Nadu, IN
3 Department of Biotechnology, Periyar Maniammai Institute of Science & Technology (Deemed to be University), Thanjavur - 613403, IN
4 Department of Biotechnology, Vivekanandha College of Arts and Sciences for Women (Autonomous), Namakkal - 637205, Tamil Nadu, IN
5 Department of Microbiology, Hindustan College of Arts and Science, Coimbatore - 641028, Tamil Nadu, IN
6 Department of Biotechnology, Periyar Maniammai Institute of Science & Technology (Deemed to be University), Thanjavur - 613403, Tamil Nadu, IN

Source

Journal of Natural Remedies, Vol 23, No 2 (2023), Pagination: 603-613

Abstract

Although a variety of economical water treatment options are available, rural residents struggle to have safe drinking water. Therefore, developing cost-effective and efficient drinking water treatment technology for the removal of selected ionic compounds and suspended solids is necessary. The present study aims to establish a cost-effective water treatment method by employing the following adsorbents Graphene Sand Composite (GSC), GSC with Moringa Oleifera seeds, Phyllanthus emblica seeds, Strychnos potatorum seeds, tea waste, sawdust, coal, coconut charcoal, and clay pot (an indigenized filter). X-ray diffraction of GSC confirms SiO2 nanoparticles, a broad peak centred at 22.5°, Graphene peaks are found at 26.73 (200), 45.8 (110) and 54.959 (222). In FT-IR, graphene oxide has a strong and wide O-H/ Si-OH stretching vibration peak at 3444 cm-1. In the Raman spectrum, the graphitic vibration band from its first-order scattering of E2g photons using sp2 carbon appeared at 1589 cm-1. Moreover, the graphitic vibration band contributes to the presence of stretching C-C bond; which is common in all sp2 carbon systems. Water’s pH, TDS, hardness, and chloride content also increased considerably in a few adsorbents. Fabricated pots with an indigenous filter using GSC and Moringa oleifera seed as filter disc has also been designed and evaluated in the present study. In this research, 100% salinity removal is achieved using GSC as an adsorbent. While there is an interesting rise trend in fluoride and calcium content to 33% and 39%, respectively. The reason for the rise in fluoride and calcium can be studied further.

Keywords

Adsorbents, Calcium, Drinking Water, Fluoride, Graphene Sand Composite, Salt

Full Text

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